葛黎明 副教授/硕士研究生生导师
研究方向：生物质化学与材料
办公地点：四川大学望江校区化工学院228室
联系方式：geliming@scu.edu.cn
个人简介：
2019年6月毕业于四川大学，获工学博士学位。研究方向为生物质化学与材料，长期从事胶原和多糖基功能性复合材料在食品和生物医药领域的应用基础研究工作。主持国家自然科学基金青年科学基金项目、四川省应用基础研究项目、四川大学博士后交叉学科创新启动基金项目、皮革化学与工程教育部重点实验室开放课题和企业委托项目等。以第一作者或通讯作者在Advanced Healthcare Materials，ACS Applied Materials & Interfaces，ACS Sustainable Chemistry & Engineering，Biomaterials Advances，Carbohydrate Polymers等学术期刊上发表了20余篇研究论文，以第一发明人获授权发明专利4件。指导本科生获得第十二届全国大学生药苑论坛“创新成果一等奖”和“优秀论文奖”，荣获四川大学大学生创新创业与实践教育优秀指导教师等荣誉。
教育经历：
2014.9-2019.6，四川大学，生物化工专业，工学博士（硕博连读），导师：穆畅道教授
2010.9-2014.6，四川大学，生物工程专业，工学学士
工作经历：
2023.9-今，四川大学，江南体育官网制药与生物工程系，副教授
2022.7-今，四川大学，江南体育官网制药与生物工程系，硕士研究生导师
2022.5-2023.8，四川大学，江南体育官网制药与生物工程系，副研究员（专职科研）
2019.7-2022.4，四川大学，江南体育官网制药与生物工程系，助理研究员
2019.7-2022.11，四川大学，化学工程与技术，专职博士后
教学工作：
主要讲授制药工程专业本科和研究生的课程：《制药工程设计》、《药品生产质量工程》、《制药工程专业文献检索与研读》、《制药生产实习》、《微生物学实验II》等。
科研项目：
1.国家自然科学基金青年科学基金项目，项目号: 22305164，2024.1~2026.12，项目负责人。
2.四川省应用基础研究项目，项目号: 2021YJ0478，2021.4~2023.3，项目负责人。
3.四川大学博士后交叉学科创新启动基金项目，2021.1~2022.12，项目负责人。
4.四川大学专职博士后研发基金，项目号: 2021SCU12085，2021.1~2022.12，项目负责人。
5.皮革化学与工程教育部重点实验室开放课题，2022.1.1~2022.12.31，项目负责人。
6.企业委托项目，合同号: 21H0387，2021.6~2023.5，项目负责人。
7.企业委托项目，合同号: 21H0986，2021.9.15~2022.2.28，项目负责人。
8.企业委托项目，合同号: 21H1052，2021.10.20~2021.12.20，项目负责人。
9.企业委托项目，合同号: 22H0955，2022.8.17-2022.11.30，项目负责人。
研究论文：
28. Weidong Liao, Die Yang, Zhilang Xu, Lei Zhao, Changdao Mu, Defu Li,Liming Ge*. Antibacterial collagen-based nanocomposite dressings for promoting infected wound healing[J].Advanced Healthcare Materials, 2023, 12(15): 2203054.
27. Xianyu Lin, Xue Yang, Panyu Li, Zhilang Xu, Lei Zhao, Changdao Mu, Defu Li,Liming Ge*. Antibacterial conductive collagen-based hydrogels for accelerated full-thickness wound healing[J].ACS Applied Materials & Interfaces, 2023, 15(19): 22817-22829.
26. Weiwei Tan, Tao Long, Yanzhuo Wan, Bingchen Li, Zhilang Xu, Lei Zhao, Changdao Mu,Liming Ge*, Defu Li*. Dual-drug loaded polysaccharide-based self-healing hydrogels with multifunctionality for promoting diabetic wound healing[J].Carbohydrate Polymers, 2023, 312: 120824.
25.王欣欣,吴霞,李德富,穆畅道,葛黎明*.明胶纳米颗粒稳定的Pickering乳液的制备及表征[J].食品与发酵工业, 2023, 49(1): 124-131.
24.谭魏葳,雷苏苏,龙涛,徐志朗,李德富,穆畅道,葛黎明*.具有葡萄糖响应性释药的多糖基可注射自愈合水凝胶[J].高分子学报, 2023, 54(8): 1155-1165.
22. Xiaxi Pan, Guixin Chen, Ting Xu, Lingyue Kong, Xinying Li, Defu Li, Changdao Mu, Zhilang Xu*, Liming Ge*. Gelatin-based active edible film with pH-sensing for maintaining and monitoring fish freshness[J].ACS Food Science & Technology, 2023, 3, 1366-1375.
21. Zhilang Xu, Die Yang, Tao Long, Lun Yuan, Shi Qiu, Defu Li, Changdao Mu,Liming Ge*.pH-Sensitive nanoparticles based on amphiphilic imidazole/cholesterol modified hydroxyethyl starch for tumor chemotherapy[J].Carbohydrate Polymers, 2022, 277: 118827.
20.葛黎明,徐锦芳,穆畅道,李德富*.双醛纤维素纳米晶Pickering乳液的制备及其释放二氢杨梅素的研究[J].食品与发酵工业, 2022, 48(23): 156-164.
19. Lun Yuan, Zijing Li, Xinying Li, Shi Qiu, Jinfeng Lei,* Defu Li, Changdao Mu,Liming Ge*. Functionalization of an injectable self-healing pH-responsive hydrogel by incorporating curcumin/polymerized β-CD inclusion complex for selective toxicity to osteosarcoma[J].ACS Applied Polymer Materials, 2022, 4(2): 1243-1254.
18. Hongmei Zhou, Lun Yuan, Zhilang Xu, Xueling Yi, Xiao Wu, Changdao Mu,Liming Ge*, Defu Li*. Mimicking the composition and structure of the osteochondral tissue to fabricate a heterogeneous three-layer scaffold for the repair of osteochondral defects[J].ACS Applied Bio Materials, 2022, 5(2), 734-746.
17. Zhilang Xu, Lun Yuan, Qisong Liu, Defu Li, Changdao Mu, Lei Zhao, Xinying Li*,Liming Ge*. Crosslinking effect of dialdehyde cholesterol modified starch nanoparticles on collagen hydrogel[J].Carbohydrate Polymers, 2022, 285: 119237.
16.Liming Ge, Zijing Li, Miao Han, Yongjie Wang, Xinying Li*, Changdao Mu, Defu Li*. Antibacterial dialdehyde sodium alginate/ε-polylysine microspheres for fruit preservation[J].Food Chemistry, 2022, 387: 132885.
15. Xueling Yi, Zhilang Xu, Qisong Liu, Hongmei Zhou, Lun Yuan, Defu Li, Lei Zhao, Changdao Mu,Liming Ge*. Matrix metalloproteinase-responsive collagen-oxidized hyaluronic acid injectable hydrogels for osteoarthritic therapy[J].Biomaterials Advances, 2022, 137: 212804.
14. Xiao Wu,Liming Ge*, Guohua Shen, Ying He, Zhilang Xu, Defu Li, Changdao Mu, Lei Zhao, Wenjie Zhang*.131I-Labeled silk fibroin microspheres for radioembolic therapy of rat hepatocellular carcinoma[J].ACS Applied Materials & Interfaces, 2022, 14(19): 21848-21859.
13. Die Yang, Shilong Yang, Mingze Mu, Xueping Liu, Lei Zhao, zhilang Xu, Changdao Mu, Defu Li*,Liming Ge*. Multifunctional β-cyclodextrin-polyethylene glycol-cholesterol nanomicelle for anti-cancer drug delivery[J].ACS Applied Bio Materials, 2022, 5(11): 5418-5431.
12. Keyan Miao, Xinying Li, Die Yang, Yongbin Xu, Changdao Mu, Defu Li,Liming Ge*. Hydrothermal shrinkage behavior of pigskin[J].Thermochimica Acta, 2021, 699: 178896.
11.李新莹,缪可言,葛黎明*,李德富*.胶原蛋白热变性检测方法的比较研究[J].皮革科学与工程, 2021, 31(3): 41-45.
10. Jinfang Xu, Xinying Li, Yaqin Xu, Anqi Wang, Zhilang Xu, Xia Wu, Defu Li, Changdao Mu,Liming Ge*. Dihydromyricetin-loaded pickering emulsions stabilized by dialdehyde cellulose nanocrystals for preparation of antioxidant gelatin-based edible films[J].Food and Bioprocess Technology, 2021, 14: 1648-1661.
9. Lei Deng, Xinying Li, Keyan Miao, Xinyan Mao, Miao Han, Defu Li, Changdao Mu,Liming Ge*. Development of disulfide bond crosslinked gelatin/ε-polylysine active edible film with antibacterial and antioxidant activities[J].Food and Bioprocess Technology, 2020, 13(4): 577-588.
8. Xi Zhao, Xinying Li, Xiaofen Xie, Jinfeng Lei,Liming Ge*, Lun Yuan, Defu Li*, Changdao Mu. Controlling the pore structure of collagen sponge by adjusting the crosslinking degree for construction of heterogeneous double-layer bone barrier membrane[J].ACS Applied Bio Materials, 2020, 3(4): 2058-2067.
7. Xiaofen Xie, Xinying Li, Jinfeng Lei, Xi Zhao, Yongbo Lyu, Changdao Mu, Defu Li,Liming Ge*, Yongbin Xu*. Oxidized starch cross-linked porous collagen-based hydrogel for spontaneous agglomeration growth of adipose-derived stem cells[J].Materials Science and Engineering: C, 2020, 116: 111165.
6.韩淼,李德荣,袁柳青,吕永博,葛黎明*,李德富,穆畅道.双醛淀粉还原制备纳米银及其在胶原基抗菌敷料中的应用[J].高分子学报, 2019, 50(4): 366-374.
5.Liming Ge, Yongbin Xu, Xinying Li, Lun Yuan, Huan Tan, Defu Li*, Changdao Mu. Fabrication of antibacterial collagen-based composite wound dressing[J].ACS Sustainable Chemistry & Engineering, 2018, 6(7), 9153-9166.
4.Liming Ge, Mingjin Zhu, Xinying Li, Yongbin Xu*, Xiaonan Ma, Rong Shi, Defu Li*, Changdao Mu. Development of active rosmarinic acid-gelatin biodegradable films with antioxidant and long-term antibacterial activities[J].Food Hydrocolloids, 2018, 83(10): 308-316.
3.Liming Ge, Mingjin Zhu, Yongbin Xu, Xinying Li*, Defu Li*, Changdao Mu. Development of antimicrobial and controlled biodegradable gelatin-based edible films containing nisin and amino-functionalized montmorillonite[J].Food and Bioprocess Technology, 2017, 10(9): 1727-1736.
2.Liming Ge, Yongbin Xu, Weijie Liang, Xinying Li*,Defu Li*, Changdao Mu. Short-range and long-range cross-linking effects of polygenipin on gelatin-based composite materials[J].Journal of Biomedical Materials Research Part A, 2016, 104(11): 2712-2722.
1.Liming Ge, Xinying Li, Run Zhang, Tianhan Yang, Xiaowei Ye, Defu Li*, Changdao Mu. Development and characterization of dialdehyde xanthan gum crosslinked gelatin based edible films incorporated with amino-functionalized montmorillonite[J].Food Hydrocolloids, 2015, 51(10): 129-135.
发明专利：
1.葛黎明,王琦,周庆,王踏秋,李德富,穆畅道,徐志朗.一种可溶性载药微针及其制备方法.申请号: 202310046516.9.
2.葛黎明,廖伟栋,杨敏轩,李德富,穆畅道.一种纳米氧化锌/胶原基抗菌敷料及其制备方法.专利号: ZL202110912392.9.
3.葛黎明,徐锦芳,陈沁菲,李德富,穆畅道.活性明胶基可食性膜及其制备与应用方法.专利号: ZL202110248712.5.
4.葛黎明,徐志朗,周昌海,王欣欣,杨丽可,周晓,李德富.一种双醛多糖纳米颗粒交联胶原水凝胶及其制备方法.专利号: ZL202010541765.1.
5.葛黎明,解晓芬,林先玉,李德富,穆畅道.一种具有促血管再生性能的胶原基细胞支架及其制备方法.专利号: ZL201910460122.1.
获得荣誉：
1.第十二届全国大学生药苑论坛“创新成果一等奖”和“优秀论文奖”，指导教师
2.第六届四川大学“互联网+”大学生创新创业大赛三等奖，指导教师
3.四川大学2019年大学生创新创业与实践教育优秀指导教师
4.全国大学生生命科学竞赛（2021，科学探究类）国赛三等奖，指导教师
5.第八届四川省大学生“生命之星”科技邀请赛二等奖，指导教师
6.第九届四川省大学生“生命之星”科技邀请赛二等奖，指导教师
7.全国大学生生命科学竞赛（2022，科学探究类）国赛三等奖，指导教师
8.四川大学2021年大学生创新创业与实践教育优秀指导教师
9.第二届四川省大学生“生命之星”科技竞赛省级三等奖，指导教师
社会兼职：
担任四川省皮革学会理事，中国化工学会会员，中国生物材料学会会员，以及担任Advanced Science，Advanced Healthcare Materials，Advanced Fiber Materials，ACS Applied Materials & Interfaces，Biomacromolecules，Carbohydrate Polymers，International Journal of Biological Macromolecules等国际期刊审稿人。
