黄文才 副教授

四川大学化工学院制药与生物工程系

联系方式：成都市一环路南一段24号四川大学化工学院（邮编610065）

E-mail: hwc@scu.edu.cn

教育背景

1993. 9 -- 1997. 7成都科技大学有机化工专业工学学士

1997. 9 -- 2000. 7四川大学应用化学专业工学硕士

2000. 9 -- 2003. 7四川大学药物化学专业理学博士

工作简历

2003. 9 -- 2005. 9中科院上海药物研究所博士后

2005. 10 --至今四川大学化工学院制药与生物工程系讲师/副教授/硕士生导师

2014. 9 -- 2015. 9美国弗吉尼亚大学化学系访问学者

教学工作

负责本科生《药物化学》、《化学制药工艺学》及研究生《药品制造工程导论》等课程的教学工作，主编《药物合成反应》（科学出版社，2021），副主编《制药工程技术概论》（化工出版社，2019）。

科研方向

1.小分子荧光探针的研究

2.药物研制与开发

3.绿色化学制药工艺研究

主持或参加国家自然科学基金、广东省-教育部产学研结合项目、四川大学校青年科研基金及多项企业合作开发项目。

代表性科研成果

1.Zhang Dan, Wang Sifan, Yang Fangxi, Qi Qingrong, Li Yanfang*,Huang Wencai*. A fluorescent probe for alkylating agents and its quantification of triflate as a genotoxic impurity. Chem. Commun., 2023,59(15): 2130-2133.

2.Zhang Dan, Wang Sifan, Yang Fangxi, Li Zicheng,Huang Wencai*. Visual inspection of acidic pH and bisulfite in white wine using a colorimetric and fluorescent probe. Food Chem.. 2023,408: 135200.

3.Zhang Zichang, Zhang Dan, Qi Qingrong, Li Zicheng,Huang Wencai*. A colorimetric and fluorometric probe for phenylhydrazine and its application in real samples. Chem. Commun., 2022,58(61): 8540-8543.

4.Zhang Zichang, Tu Liangping, Zhang Dan, Li Zicheng,Huang Wencai*. Comparative studies on the absorption and fluorescence responses of hemicyanine to HSO₃^-, CN^-, HS^-and ClO^-. Spectrochim. Acta A, 2022,269: 120781.

5.Tu Liangping, Liu Jian, Zhang Zichang, Qi Qingrong, Yao Shun,Huang Wencai*. Micheal addition reaction-based fluorescent probe for malononitrile detection and its applications in aqueous solution, living cells and zebrafish. Analyst,2021,146(7): 2221-2228.

6.Wang Shun, Liu Jian,Song Linjiang, Qi Qingrong*, Li Zicheng, Huang Wencai*.A selective and sensitive near-infrared fluorescent probe for in vivo real time tracking of exogenous and metabolized hydrazine, a genotoxic impurity. J. Mater. Chem. B, 2020,8(45): 10353-10359.

7.Zhang Yi, Tu Liangping, Lu Lingling, Li Yuxiao, Song Linjiang,* Qi Qingrong, Song Hang, Li Zicheng,Huang Wencai*.Screening and application of boron difluoride complex of curcumin as a colorimetric and ratiometric fluorescent probe for bisulfite. Anal. Methods, 2020,12(11): 1514-1521.

8.Liu Jian, Li Tao, Wang Shun, Qi Qingrong, Song Hang, Li Zicheng, Yang Li*,Huang Wencai*. A sensitive and selective fluorescent probe for hydrazine with a unique nonaromatic fluorophore. RSC Adv.,2020,10: 5572-5578.

9.Li Tao, Liu Jian, Song Linjiang, Li Zicheng, Qi, Qingrong*,Huang Wencai*. A hemicyanine-based fluorescent probe for hydrazine detection in aqueous solution and its application in real time bioimaging of hydrazine as a metabolite in mice. J. Mater. Chem. B, 2019,7: 3197-3200.

10.Li Yuan, Ji Yu-Xin, Song Lin-Jiang, Zhang Yi, Li Zi-Cheng, Yang Li,Huang Wen-Cai*. A novel BF₂-curcumin-based fluorescent chemosensor for detection of Cu²⁺in aqueous solution and living cells. Res. Chem. Intermed., 2018,44(9): 5169-5180.

11.Zhou Ji-Cai, Zhao Lei, Li Yuan, Fu Ding-Qiang, Li Zi-Cheng,Huang Wen-Cai*. Alkynylation of aldehydes mediated by Zinc and allyl bromide: a practical synthesis of propargylic alcohols. Res. Chem. Intermed., 2017,43(7):4283-4294.

12.Zhang Yun-Hao, Wu Ming-Yue,Huang Wen-Cai^*. Silica gel-promoted practical synthesis of oxindole-nitrones from diazooxindoles and nitrosoarenes under solvent-free conditions. RSC Adv., 2015,5(128): 105825-105828.

13.Huang Wen-Cai, Liu Winnie, Wu Xue-Dan, Ying Jun, Pu Lin*. Highly enantioselective alkyne addition to aliphatic, aromatic and vinyl aldehydes by using Zn,ⁱPrI, H₈BINOL and Ti(OⁱPr)₄. J. Org. Chem., 2015,80(22): 11480-11484.

14.Xie J. Y., Liu J. Q., Zhang Y. H., Li J. J., Li Z. C.,Huang W. C.*. An improved preparation of 2, 6-di-tert-butyl-4-methylphenol. Org. Prep. Proced. Int., 2015,47(3): 236-241.

15.Liu Junqiang, Mi Chenggen, Tang Xuemei, Cao Yuan, Li Zicheng,Huang Wencai*. Facilemicrowave-assisted synthesis of substituted benzofuran derivatives. Res. Chem. Intermed., 2014,40(5): 2083-2090.

16.Yang Li, Lei Hua, Mi Cheng-Gen, Liu Huan, Zhou Tian, Zhao Ying-Lan, Lai Xiao-Yun, Li Zi-Cheng, Song Hang,Huang Wen-Cai*. Synthesis, antiproliferative activities and in vitro biological evaluation of novel benzofuransulfonamide derivatives. Bioorg. Med. Chem. Lett., 2011,21(18): 5389-5392.

17.Luo Xin-Feng, He Ling, Yin Hai-Bin, Zheng Hu, Bei Di, Deng Jin-Jin,Huang Wen-Cai*. Efficient acylation and one-pot synthesis of dehydroandrographolide succinate on a large scale assisted with microwave radiation. Synth. Commun., 2009,39(19): 3444-3452.

18.Huang Wencai, Zheng Hu, Weng Lingling. Synthesis of tetracycline analogs and their bone affinities. Chin. Chem. Lett., 2008,19(1): 19-22.

19.黄文才,张丹,程度,张春红,陈文芝,雷华.一种三水合3-氨基丙基胺乙基硫代磷酸的合成方法.中国发明专利, ZL 201110152336.6, 2014-2-26.